The effect of methenamine mandelate (mandelamine) on determination of urinary estriol.
نویسندگان
چکیده
The administration of methenamine mandelate (Mandelamine) to pregnant women causes the levels of estriol in their urines to be unmeasurably low when acid hydrolysis is used. When enzyme hydrolysis replaces acid hydrolysis, normal estriol values are obtained. This result is attributed to the formaldehyde released by acid from hexamethylenetetramine, a constituent of the drug. The formaldehyde reacts with estriol to prevent its determination.
منابع مشابه
Interference by formaldehydogenic drugs in the quantitative determination of urinary hydroxyindoleacetic acid.
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متن کاملDetermination of urinary formaldehyde following administration of methenamine salts.
C TJRRENT COLORIMETRIC METHODS for the measurement of formaldehyde in the presence of methenamine salts appear misleading. The principal problems with these technics include the release of formaldehyde (1, 2) from intact methenamine and the nonspecificity of the reaction producing color with other compounds present in urine. However, a modification of the method of Tannenbaum and Bricker (3) ap...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 11 11 شماره
صفحات -
تاریخ انتشار 1965